Home Antibody All anti-HDAC8 antibodies
Also for HDAC8 (NM_001166418)
|E. coli-expressed recombinant human HDAC8|
||WB: 0.5-4 ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Homo sapiens histone deacetylase 8 (HDAC8), transcript variant 2|
|CDA07; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS|
Entrez Gene 55869 Human
|Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).|
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Western blot analysis using recombinant human HDAC8. Lane 1: 30 ng, Lane 2: 60 ng, Lane 3: 120 ng, Lane 4: 250 ng.