Home Antibody All anti-Tyrobp antibodies
Also for Tyrobp (NM_198125)
|Synthetic peptide corresponding to residues surrounding amino acids 94 of mouse DAP-12|
||WB: 0.5-4 ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 2|
|DAP12; KARAP; PLOSL|
Entrez Gene 22177 Mouse
Entrez Gene 361537 Rat
|DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.|
|TransmembraneDruggable Genome Natural killer cell mediated cytotoxicity|
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Western blot analysis of DAP12 expression in rat kidney tissue lysate.