Home Antibody All anti-TGFB2 antibodies
Also for TGFB2 (NM_003238)
|Synthetic peptide surrounding amino acid 366 of human TGF-ß2 |
|Human, mouse, rat
||WB: 0.5-4 ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens transforming growth factor, beta 2 (TGFB2), transcript variant 2|
|The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. |
Cytokine-cytokine receptor interaction
MAPK signaling pathway
TGF Beta Signaling Pathway
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Western blot analysis of TGF-beta2 using Jurkat cell lysate (Lane 1,2), Mouse 3T3 cell lysate (Lane 3) and Rat kidney tissue lysate (Lane 4).