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Home Antibody All anti-Insig1 antibodies

Anti-Insig1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA318983
  • Rabbit polyclonal anti-Insig1 antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC405025) , 20ug
100ug $325 3-7 Days
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WB(1)
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Also for Insig1 (NM_198336)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSynthetic peptide surrounding amino acid 248 of rat Insig1
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat, bovine, hamster Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4 ug/ml
Buffer100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens insulin induced gene 1 (INSIG1), transcript variant 2
Alternative NameCL-6; CL6
Database LinkNP_938150
FunctionInsulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
Related Pathway

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WB Image
Western blot analysis of InSig1 expression in Jurkat cell lysate.

 

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