Home Antibody All anti-Insig1 antibodies
Also for Insig1 (NM_198336)
|Synthetic peptide surrounding amino acid 248 of rat Insig1|
|Human, mouse, rat, bovine, hamster
||WB: 0.5-4 ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Homo sapiens insulin induced gene 1 (INSIG1), transcript variant 2|
Entrez Gene 3638 Human
Entrez Gene 231070 Mouse
Entrez Gene 64194 Rat
|Insulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes. |
|TransmembraneDruggable Genome |
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Western blot analysis of InSig1 expression in Jurkat cell lysate.