Home Antibody All anti-PMAIP1 antibodies
Also for PMAIP1 (NM_021127)
|Synthetic peptide surrounding amino acid 100 of human Noxa|
|Human, mouse, rat
|100 µg (0.2mg/ml) protein A purified rabbit anti-Noxa polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal.|
|Homo sapiens phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)|
Entrez Gene 5366 Human
Entrez Gene 58801 Mouse
Entrez Gene 492821 Rat
|Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These suggest Noxa may represent a candidate mediator of p53-induced apoptosis.|
|Stem cell - PluripotencyDruggable Genome p53 signaling pathway|
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Western blot analysis of Noxa expression in Jurkat cell lysate.