Home Antibody All anti-Pax6 antibodies
Also for Pax6 (NM_000280)
|Synthetic peptide surrounding amino acid 303 of rat PAX6|
|Human, mouse, rat
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Homo sapiens paired box 6 (PAX6), transcript variant 1|
|AN; AN2; D11S812E; FVH1; MGDA; WAGR|
Entrez Gene 5080 Human
Entrez Gene 18508 Mouse
Entrez Gene 25509 Rat
|PAX genes encode nuclear transcription factors that may function as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters’ anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.|
|Adult stem cellsEmbryonic stem cellsTranscription FactorsDruggable Genome Maturity onset diabetes of the young|
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Western blot analysis of PAX6 with rat kidney tissue lysate.