Home Antibody All anti-Wnt6 antibodies
Also for Wnt6 (NM_006522)
|Synthetic peptide surrounding amino acid 276 of mouse Wnt-6|
|Human, mouse, rat
||WB: 0.5-4 ug/ml, IHC: 10-20ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit Wnt-6 polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens wingless-type MMTV integration site family, member 6 (WNT6)|
|wingless-type MMTV integration site family, member 6|
|Wnt gene family members, including Wnt-1 through Wnt-10, play a key role in regulating cellular growth and differentiation. Wnt-1 is a cysteine-rich, secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-1, which is essential for normal development of the embryonic nervous system, contributes to hyperplasia and tumorigenic progression when improperly expressed in mammary tissue. Wnt-3 is involved in tumorigenesis and Wnt-2 and Wnt-4 may be associated with abnormal proliferation in human breast tissue. Wnt-6 is involved in oncogenesis and is co-expressed with Wnt10 in colorectal cancer cell lines. The presence of cervical and breast cell carcinomas may indicate an over expression of Wnt-6. |
Hedgehog signaling pathway
Wnt Signaling Pathway
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Western blot analysis of Wnt-6 expression in rat kidney tissue lysate.