Home Antibody All anti-STAT5B antibodies
Also for STAT5B (NM_012448)
|Synthetic peptide surrounding amino acid 777 of human Stat5|
|Human, mouse, rat
||WB: 2-10 ug/ml, IHC: 20ug/ml, IP: 20ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS).|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens signal transducer and activator of transcription 5B (STAT5B)|
|Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3ß appears to be activated by both while Stat3a is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.|
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
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Western blot analysis of Stat-5 expression in 3T3 cell lysate (Lane 1) and rat kidney tissue lysate (Lane 2).