Home Antibody All anti-Creb1 antibodies
Also for Creb1 (NM_004379)
|Synthetic peptide surrounding amino acid 109 of rat CREB|
|Human, mouse, rat
||WB: 0.5-4ug/ml, IHC: 5ug/ml
|100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens cAMP responsive element binding protein 1 (CREB1), transcript variant A|
|Transcription factor CREB binds the cAMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinase CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Phosphorylation at Ser133 is also mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase and MSK1. CREB appears to play an important role in learning and memory in both flies and mice.|
EGFR1 Signaling Pathway
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Western blot analysis of CREB in 3T3 cell lysate.