Home Antibody All anti-Tnfrsf21 antibodies
Also for Tnfrsf21 (NM_014452)
|Synthetic peptide surrounding amino acid 622 of rat DR6|
|Human, mouse, rat
|100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-DR6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.|
|Homo sapiens tumor necrosis factor receptor superfamily, member 21 (TNFRSF21)|
|BM-018; CD358; DR6|
Entrez Gene 27242 Human
Entrez Gene 94185 Mouse
Entrez Gene 316256 Rat
|Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptor including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines. |
|TransmembraneDruggable Genome Cytokine-cytokine receptor interaction|
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Western blot analysis of DR6 expression in lysate from Jurkat cells (Lane 1, 2), 3T3 cells (Lane 3) and rat kidney tissue lysate (Lane 4).