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Home Antibody All anti-Tnfrsf21 antibodies

Anti-Tnfrsf21 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA318878
  • Rabbit polyclonal anti-Tnfrsf21 (DR6) antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402336) , 20ug
100ug $325 In Stock
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WB(1)
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Also for Tnfrsf21 (NM_014452)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSynthetic peptide surrounding amino acid 622 of rat DR6
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat Concentration0.5mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4ug/ml
Buffer100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-DR6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 21 (TNFRSF21)
Alternative NameBM-018; CD358; DR6
Database LinkNP_055267
FunctionApoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptor including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines.
Related Pathway
Apoptosis
Cytokine-cytokine receptor interaction

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WB Image
Western blot analysis of DR6 expression in lysate from Jurkat cells (Lane 1, 2), 3T3 cells (Lane 3) and rat kidney tissue lysate (Lane 4).

 

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