Home Antibody All anti-CD40 antibodies
Also for CD40 (NM_152854)
|Synthetic peptide corresponding to residues surrounding amino acids 261 of human CD40|
|Human, mouse, rat, monkey, pig
|100 µg (0.2 mg/ml) immunoaffinity purified rabbit anti-CD40 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 2|
|Bp50; CDW40; p50; TNFRSF5|
|CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with T cells expressing CD40L, and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells, CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6, a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.|
Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
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Western blot analysis of CD40 expression in rat kidney tissue lysate.