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Home Antibody All anti-PARP1 antibodies

Anti-PARP1 Antibody 7A10


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA318859 Mouse monoclonal anti-PARP antibody, clone 7A10 100ul $582 In Stock
LC400609 PARP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues before the cleavage site of human PARP-1 was used as immunogen. The antibody only recognizes full-length form (p116) of PARP-1.
Clone Name7A10 IsotypeMouse
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:500-2000, IF: 1:200-400
BufferSupplied in 10 mM HEPES sodium (pH 7.5), 150 mM NaCl, 100  µg/ml BSA, 50% glycerol, and 0.03% sodium azide
Purification N/A

Reference Data

Target Namepoly(ADP-ribose) polymerase 1
Database LinkNP_001609
Entrez Gene 142 Human
FunctionPARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis using PARP mouse mAb against Jurkat (1), K562 (2), HeLa (3), Raji (4), THP-1 (5) and SW620 (6) cell lysate.

FC Image
Flow cytometric analysis of Jurkat cells using anti-PARP mAb (green) and negative control (purple).


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