Anti-ZFYVE9 Antibody, EPR5020

Also for ZFYVE9 (NM_004799)

Gene Name	Homo sapiens zinc finger, FYVE domain containing 9 (ZFYVE9), transcript variant 3
Synonyms:	MADHIP; NSP; SARA; SMADIP
Immunogen	A synthetic peptide corresponding to residues at the N-terminus of human SARA was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR5020	Isotype
Species Reactivity	Human, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000; FC: 1:100 - 500;
Background	SARA is a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. SARA functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of SARA interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor (1).
Related Pathway	TGF Beta Signaling Pathway

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WB Image

Western blot analysis on (A) human heart, (B) A673, (C) HT-1080, and (D) BxPC-3 cell lysates using anti-SARA RabMAb.

WB Image

Western blot analysis on (A) Jurkat, (B) HeLa, and (C) fetal brain lysates using anti-SARA RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SARA RabMAb.

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Anti-ZFYVE9 Antibody EPR5020

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