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Home Antibody All anti-ZBTB33 antibodies

Anti-ZBTB33 Antibody EPR4668

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA311110
  • Rabbit Monoclonal antibody against Kaiso (ZBTB33)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC433416) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for ZBTB33 (NM_001184742)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Kaiso was used as an immunogen.
Clone NameEPR4668 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens zinc finger and BTB domain containing 33 (ZBTB33), transcript variant 1
Alternative NameZNF-kaiso; ZNF348
Database LinkNP_001171671
FunctionKaiso is a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus Kaiso-binding site TCCTGCNA. It contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target promoters. Kaiso may contribute to the repression of targets of the Wnt signaling pathway, and it may also activate transcription of a subset of targets by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of Kaiso (1).
Related Pathway
Wnt Signaling Pathway

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WB Image
Western blot - Anti-Kaiso antibody [EPR4668]; All lanes : Anti-Kaiso antibody [EPR4668] at 1/1000 dilution.Lane 1 : Human heart lysate.Lane 2 : MCF7 lysate.Lane 3 : C6 lysate.Lane 4 : PC12 lysate.Lane 5 : NIH 3T3 lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled Goat anti Rabbit IgG at 1/2000 dilution.Predicted band size : 74 kDa.Observed band size : 95 kDa .

 

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