Home All anti-UIMC1 antibodies
Anti-UIMC1 Antibody EPR5315
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Also for UIMC1 (NM_001199297)
|A synthetic peptide corresponding to residues in human RAP80 was used as an immunogen.|
||WB: 1:1,000 - 10,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens ubiquitin interaction motif containing 1 (UIMC1), transcript variant 1|
|RAP80 is an ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1/BARD1 complex to sites of DNA damage at double-strand breaks (1). RAP80 contains an ubiquitin-interaction motif (UIM) that is associated with the complex through its interaction with CCDC98. Furthermore, it is reported to interact with the estrogen receptor a (ERa) in an agonist-dependent manner and is able to regulate ERa transcriptional activity (2).|
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Western blot analysis on (A) HeLa, (B) ovary cancer, (C) 293T, and (D) HT-1080 lysates using anti-RAP80 RabMAb.
Immunohistochemical analysis of paraffin-embedded human testis tissue using anti-RAP80 RabMAb.