Anti-UIMC1 Antibody, EPR5315

Also for UIMC1 (NM_001199297)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human RAP80 was used as an immunogen.
Clone Name	EPR5315	Isotype
Species Reactivity	Human	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens ubiquitin interaction motif containing 1 (UIMC1), transcript variant 1
Alternative Name	RAP80; X2HRIP110
Database Link	NP_001186226
Function	RAP80 is an ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1/BARD1 complex to sites of DNA damage at double-strand breaks (1). RAP80 contains an ubiquitin-interaction motif (UIM) that is associated with the complex through its interaction with CCDC98. Furthermore, it is reported to interact with the estrogen receptor a (ERa) in an agonist-dependent manner and is able to regulate ERa transcriptional activity (2).
Related Pathway

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WB Image

Western blot analysis on (A) HeLa, (B) ovary cancer, (C) 293T, and (D) HT-1080 lysates using anti-RAP80 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human testis tissue using anti-RAP80 RabMAb.

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

HRP
Biotin
PE
FITC
DyLight® 488
DyLight® 550
DyLight® 594
DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-UIMC1 Antibody EPR5315

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data