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Home Antibody All anti-UIMC1 antibodies

Anti-UIMC1 Antibody EPR5315

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA311101
  • Rabbit Monoclonal antibody against RAP80 (UIMC1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414063) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RAP80 was used as an immunogen.
Clone NameEPR5315 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:250 - 1:500; ICC/IF: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens ubiquitin interaction motif containing 1 (UIMC1), transcript variant 1
Alternative NameRAP80; X2HRIP110
Database LinkNP_001186226
FunctionRAP80 is an ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1/BARD1 complex to sites of DNA damage at double-strand breaks (1). RAP80 contains an ubiquitin-interaction motif (UIM) that is associated with the complex through its interaction with CCDC98. Furthermore, it is reported to interact with the estrogen receptor a (ERa) in an agonist-dependent manner and is able to regulate ERa transcriptional activity (2).
Related Pathway

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WB Image
Western blot - Anti-RAP80 antibody [EPR5315]; All lanes : Anti-RAP80 antibody [EPR5315] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Human ovary cancer lysate.Lane 3 : 293T cell lysate.Lane 4 : HT-1080 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 80 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAP80 antibody [EPR5315]; TA311101, at 1/250, staining RAP80 in paraffin-embedded Human testis tissue by Immunohistochemistry.

 

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