Anti-TNFRSF11B Antibody, EPR3592

Also for TNFRSF11B (NM_002546)

Gene Name	Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
Synonyms:	OCIF; OPG; TR1
Immunogen	A synthetic peptide corresponding to residues in human Osteoprotegerin was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR3592	Isotype
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC, IF	Suggested Dilutions	WB: 1:1,000-10,000;
Background	Osteoprotegerin is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. Osteoprotegerin specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification (1).
Related Pathway	Cytokine-cytokine receptor interaction

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WB Image

Western blot analysis on fetal kidney lysate using anti-Osteoprotegerin RabMAb.

WB Image

Western blot analysis on Osteoprotegerin recombinant protein fragment (N-term, 174 amino acid residues) (10ng) using anti-Osteoprotegerin RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Osteoprotegerin RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human heart tissue using anti-Osteoprotegerin RabMAb.

IF Image

Immunofluorescent staining of HeLa cells using anti-Osteoprotegerin RabMAb.

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Anti-TNFRSF11B Antibody EPR3592

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