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Anti-SESN1 Antibody EPR1930(2)
Also for SESN1 (NM_014454)
|A synthetic peptide corresponding to residues in human Sestrin-1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, FC
||WB: 1:1000 - 1:10000; FC: 1:100 - 1:500
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens sestrin 1 (SESN1), transcript variant 1|
Entrez Gene 27244 Human
Entrez Gene 140742 Mouse
Entrez Gene 294518 Rat
|Sestrin-1 is a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. Sestrin-1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. This protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of Sestrin-1 is a potential marker for exposure to radiation (1). |
| p53 signaling pathway|
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Western blot - Anti-SESN1 antibody [EPR1930(2)]; All lanes : Anti-SESN1 antibody [EPR1930(2)] at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : K562 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : C2C12 cell lysate.Lane 5 : NIH3T3 cell lysate.Lane 6 : F9 cell lysate.Lane 7 : JAR cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 57 kDa.
Other-Anti-SESN1 antibody [EPR1930(2)](TA311066); Equilibrium disassociation constant (KD)..
Flow Cytometry - Anti-SESN1 antibody [EPR1930(2)]; Flow Cytometry analysis of permeabilized K562 cells labelling SESN1 with TA311066 at 1/100 dilution (red). Rabbit IgG (negative control) shown in green.