MDA-9 was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. It may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. MDA-9 is primarily localized to membrane-associated adherens junctions and focal adhesions, but it is also found at the endoplasmic reticulum and nucleus (1).
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