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Home Antibody All anti-RPSA antibodies

Anti-RPSA Antibody EPR8469

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA311054 Rabbit Monoclonal antibody against Laminin Receptor (RPSA) 100ul $325 In Stock
LC423324 RPSA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(2)
FC(1)
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Also for RPSA (NM_001012321)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Laminin Receptor was used as an immunogen.
Clone NameEPR8469 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250; IP: 1:10 - 1:100; FC: 1:100 - 1:1000
Predicted MW Explanation 33 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens ribosomal protein SA (RPSA), transcript variant 2
Alternative Name37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA
Database LinkNP_001012321
Entrez Gene 3921 Human
Entrez Gene 16785 Mouse
Entrez Gene 29236 Rat
FunctionLaminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. Laminin Receptor is a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kDa laminin receptor, 37 kDa laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of Laminin Receptor is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor is higher in colon carcinoma tissue and a lung cancer cell line than their normal counterparts. In addition, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotypes (1).
Related PathwayDruggable Genome Ribosome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-67kDa Laminin Receptor antibody [EPR8469]; All lanes : Anti-67kDa Laminin Receptor antibody [EPR8469] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : C6 cell lysate.Lane 5 : RAW 264.7 cell lysate.Lane 6 : PC-12 cell lysate.Lane 7 : NIH/3T3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 33 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-67kDa Laminin Receptor antibody [EPR8469]; Immunohistochemical analysis of paraffin-embedded Human breast tissue labelling 67kDa Laminin Receptor with TA311054 at 1/100 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-67kDa Laminin Receptor antibody [EPR8469]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue labellig 67kDa Laminin Receptor with TA311054 at 1/100 dilution.
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Flow Cytometry - Anti-67kDa Laminin Receptor antibody; Overlay histogram showing MCF7 cells stained with TA311054 (red line). The secondary antibody used was Alexa Fluor 488 goat anti-rabbit IgG (H&L) at 1:2000. Isotype control antibody (black line) was rabbit IgG (monoclonal) used under the same conditions. Unlabelled sample (blue line) was also used as a control. This antibody gave a positive signal in MCF7 cells under the same conditions.
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