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Home Antibody All anti-PIK3C3 antibodies

Anti-PIK3C3 Antibody EPR5301


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA311028 Rabbit Monoclonal antibody against PI3-Kinase Class 3 (VPS34) (PIK3C3) 100ul $325 In Stock
LC400941 PIK3C3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for PIK3C3 (NM_002647)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PI3-Kinase Class 3 (VPS34) was used as an immunogen.
Clone NameEPR5301 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
Predicted MW Explanation 102 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), transcript variant 1
Alternative NamehVps34; VPS34
Database LinkNP_002638
Entrez Gene 5289 Human
Entrez Gene 225326 Mouse
Entrez Gene 65052 Rat
FunctionPI3-Kinase Class 3 (VPS34) is the catalytic subunit of the PI3K complex. It is involved in the transport of lysosomal enzyme precursors to lysosomes and the induction of autophagy during nutrient deprivation (1, 2). Thus, PI3-Kinase Class 3 (VPS34) regulates intracellular vesicular transport at multiple steps through the production of phosphatidylinositol-3-phosphate (PI(3)P). Certain downstream effectors are involved in each of the processes that PI3-Kinase Class 3 (VPS34) regulates. It exerts its function through the recruitment of proteins that contain PI(3)P-binding motifs such as FYVE or PX domains (3). PI3-Kinase Class 3 (VPS34) is also required for the activation of the mTOR (mammalian target of rapamycin)/S6K1 (S6 kinase 1) pathway, which regulates protein synthesis in response to nutrient availability (2).
Related PathwayDruggable Genome Inositol phosphate metabolismMetabolic pathwaysPhosphatidylinositol signaling systemRegulation of autophagy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-PI 3 Kinase Class 3 antibody [EPR5301]; All lanes : Anti-PI 3 Kinase Class 3 antibody [EPR5301] at 1/1000 dilution.Lane 1 : L6 cell lysate.Lane 2 : C2C12 cell lysate.Lane 3 : 293T cell lysate.Lane 4 : Mouse brain tissue lysate.Lane 5 : SHSY-5Y cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 102 kDa.Observed band size : 100 kDa .

Assay Image
Other-Anti-PI 3 Kinase Class 3 antibody [EPR5301](TA311028); Equilibrium disassociation constant (KD)..

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI 3 Kinase Class 3 antibody [EPR5301]; TA311028, at 1/50 dilution, staining PI 3 Kinase in paraffin-embedded Human gastric adenocarcinoma tissue by Immunohistochemistry.


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