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Home Antibody All anti-NONO antibodies

Anti-NONO Antibody EPR5269

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA311009
  • Rabbit Monoclonal antibody against p54nrb (NONO)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC428867) , 20ug
100ul $325 In Stock
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WB(1)
IHC(1)
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Also for NONO (NM_001145408)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human p54nrb was used as an immunogen.
Clone NameEPR5269 IsotypeTissue culture supernatant
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100; FC: 1:10 - 1:100
BufferDoes not react with Rat. Is unsuitable for IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens non-POU domain containing, octamer-binding (NONO), transcript variant 1
Alternative NameNMT55; NRB54; P54; P54NRB
Database LinkNP_001138880
Functionp54nrb (NONO) is a DNA- and RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing (1). As part of the splicesomal complex, PTB-associated RNA splicing factor (PSF) and p54nrb are essential for both step I and II pre-mRNA splicing reactions (2). p54nrb is a component of the SFPQ-NONO complex, which is associated with MATR3 and plays a role in nuclear retention of defective RNA’s. The complex is involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (3). A rearrangement between p54nrb and the transcription factor E3 has been observed in papillary renal cell carcinoma (1).
Related Pathway

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WB Image
Western blot - nmt55 / p54nrb antibody [EPR5269]; All lanes : Anti-nmt55 / p54nrb antibody [EPR5269] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lane 3 : Molt-4 cell lysate.Lane 4 : PC-3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 54 kDa.Observed band size : 54 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - nmt55 / p54nrb antibody [EPR5269]; Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using TA311009 at a dilution of 1/50.

 

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