Anti-ITGAV Antibody, EPR5583

Also for ITGAV (NM_001144999)

Gene Name	Homo sapiens integrin, alpha V (ITGAV), transcript variant 2
Synonyms:	CD51; MSK8; VNRA; VTNR
Immunogen	A synthetic peptide corresponding to residues in the intracellular domain of human CD51 / Integrin alpha-V was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR5583	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, FC	Suggested Dilutions	WB: 1:1,000 - 10,000; IP: 1:10 - 100;
Background	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing CD51 / Integrin alpha-V undergoes post-translational cleavage to yield disulfide-linked heavy chain (125 kDa) and light chain (25 kDa), which combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the CD51 / Integrin alpha-V, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction (1).
Related Pathway	Focal Adhesion Hemostasis

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WB Image

Western blot analysis on (A) A549, (B) A431, (C) C6, (D) RAW264.7, (E) PC-12, and (F) NIH/3T3 cell lysates using anti-CD51 / Integrin alpha-V RabMAb.

FC Image

Flow cytometric analysis of permeabilized A549 cells using anti-CD51 / Integrin alpha-V RabMAb (red) or a rabbit IgG (negative) (green).

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Anti-ITGAV Antibody EPR5583

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