Anti-ITGA2B Antibody, EPR4330

Also for ITGA2B (NM_000419)

Gene Name	Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B)
Synonyms:	BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3
Immunogen	A synthetic peptide corresponding to residues in the extracellular domain in human CD41 / Integrin alpha 2b was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR4330	Isotype
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:10,000 - 50,000; IHC 1:50 - 100;
Background	CD41 is also known as integrin alpha 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD41 / Integrin alpha 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling.
Related Pathway	Focal Adhesion Hematopoietic cell lineage Hemostasis

* Shipping is in business days

* OriGene provides validated application data and protocol, with money back guarantee.

WB Image

Western blot analysis on (A) human platelet, (B) fetal liver, and (C) human placenta lysates using anti-CD41 / Integrin alpha 2b RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD41 / Integrin alpha 2b RabMAb.

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

HRP
Biotin
PE
FITC
DyLight® 488
DyLight® 550
DyLight® 594
DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

OriGene Antibodies in recent publications

Anti-ITGA2B Antibody EPR4330

TrueMAB™ Antibodies - Made against Authentic Protein Antigens