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Anti-WRN Antibody EPR6392

WB(1)

Gene Name Homo sapiens Werner syndrome, RecQ helicase-like (WRN) Synonyms: RECQ3; RECQL2; RECQL3 Immunogen A synthetic peptide corresponding to residues near the C-terminus of human WRN was used as an immunogen. Buffer Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. Clone Name EPR6392 Isotype Species Reactivity Human Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB Suggested Dilutions WB: 1:50,000 - 200,000; IP: 1:10 - 100; FC: 1:10 - 100; Background WRN is a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, WRN may be involved in the repair of double strand DNA breaks. Defects in this protein are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging (1). Related Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • WRN - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • WRN - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Wrn - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • WRN - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Wrn - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens Werner syndrome, RecQ helicase-like (WRN) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens Werner syndrome, RecQ helicase-like (WRN) as transfection-ready DNA Related cDNA Clones • Homo sapiens Werner syndrome, RecQ helicase-like (WRN) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)