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Home Antibody All anti-ULK1 antibodies

Anti-ULK1 PHOSPHO Antibody EPR6156

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310925
  • Rabbit Monoclonal antibody against ULK1, pS556 (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
Assay(1)
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Also for ULK1 (NM_003565)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 556 of human ULK1 was used as an immunogen. This antibody only detects ULK1 phosphorylated at Serine 556.
Clone NameEPR6156 IsotypeIgG
Species ReactivityMouse, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:10000 - 1:50000
Predicted MW Explanation 112 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens unc-51 like autophagy activating kinase 1 (ULK1)
Alternative NameATG1; ATG1A; hATG1; UNC51; Unc51.1
Database LinkNP_003556
Entrez Gene 8408 Human
Entrez Gene 22241 Mouse
FunctionULK1 is a serine/threonine kinase that promotes autophagy signaling (1). It forms a complex with mammalian Atg13 (mAtg13) and FIP200. In this complex, mAtg13 mediates the interaction between FIP200 and ULK1 and is required for the phosphorylation of FIP200 by ULK1 in response to nutrient starvation. mTORC1 associates with the ULK1-mAtg13-FIP200 complex through an interaction between raptor and ULK1, phosphorylating ULK1 and mAtg13 to repress the kinase activity of ULK1, thereby suppressing the initiation of autophagy (2). Moreover, ULK1 is involved in the regulation of neurotransmitter trafficking and axonal growth (3).
Related PathwayProtein KinaseDruggable Genome Regulation of autophagymTOR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-ULK1 (phospho S556) antibody [EPR6156]; All lanes : Anti-ULK1 (phospho S556) antibody [EPR6156] at 1/10000 dilution.Lane 1 : ULK1 transfected 293T cell lysate untreated.Lane 2 : ULK1 transfected 293T cell lysate treated with Lambda Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 112 kDa.Observed band size : 120 kDa .
Assay Image
Other-Anti-ULK1 (phospho S556) antibody [EPR6156](TA310925); Equilibrium disassociation constant (KD)..

 

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