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Anti-ULK1 PHOSPHO Antibody EPR6154
Also for ULK1 (NM_003565)
|A phospho specific peptide corresponding to residues surrounding Serine 623 of human ULK1 was used as an immunogen. This antibody only detects ULK1 phosphorylated at Serine 623.|
||Tissue culture supernatant
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens unc-51 like autophagy activating kinase 1 (ULK1)|
|ATG1; ATG1A; hATG1; UNC51; Unc51.1|
Entrez Gene 8408 Human
Entrez Gene 22241 Mouse
|ULK1 is a serine/threonine kinase that promotes autophagy signaling (1). It forms a complex with mammalian Atg13 (mAtg13) and FIP200. In this complex, mAtg13 mediates the interaction between FIP200 and ULK1 and is required for the phosphorylation of FIP200 by ULK1 in response to nutrient starvation. mTORC1 associates with the ULK1-mAtg13-FIP200 complex through an interaction between raptor and ULK1, phosphorylating ULK1 and mAtg13 to repress the kinase activity of ULK1, thereby suppressing the initiation of autophagy (2). Moreover, ULK1 is involved in the regulation of neurotransmitter trafficking and axonal growth (3).|
|Protein KinaseDruggable Genome Regulation of autophagymTOR signaling pathway|
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Western blot - Anti-ULK1 (phospho S62) antibody [EPR6154]; All lanes : Anti-ULK1 (phospho S623) antibody [EPR6154] at 1/1000 dilution.Lane 1 : ULK1 transfected 293T cell lysate - untreated.Lane 2 : ULK1 transfected 293T cell lysate - treated with Lambda phosphatase.Lysates/proteins at 10 ug per lane.Predicted band size : 112 kDa.