Anti-ULK1 Antibody, EPR4885(2)

Also for ULK1 (NM_003565)

Gene Name	Homo sapiens unc-51-like kinase 1 (C. elegans) (ULK1)
Synonyms:	ATG1; ATG1A; hATG1; UNC51; Unc51.1
Immunogen	A synthetic peptide corresponding to residues in human ULK1 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR4885(2)	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000; FC: 1:100 - 500;
Background	ULK1 is a serine/threonine kinase that promotes autophagy signaling (1). It forms a complex with mammalian Atg13 (mAtg13) and FIP200. In this complex, mAtg13 mediates the interaction between FIP200 and ULK1 and is required for the phosphorylation of FIP200 by ULK1 in response to nutrient starvation. mTORC1 associates with the ULK1-mAtg13-FIP200 complex through an interaction between raptor and ULK1, phosphorylating ULK1 and mAtg13 to repress the kinase activity of ULK1, thereby suppressing the initiation of autophagy (2). Moreover, ULK1 is involved in the regulation of neurotransmitter trafficking and axonal growth (3).
Related Pathway	Senescence and Autophagy

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WB Image

Western blot analysis on (A) 293T, (B) U87-MG, (C) PC-12, (D) fetal muscle, and (E) SH-SY5Ycell lysates using anti-ULK1 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ULK1 RabMAb.

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Anti-ULK1 Antibody EPR4885(2)

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