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Home Antibody All anti-UCHL3 antibodies

Anti-UCHL3 Antibody EP5331

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310917
  • Rabbit Monoclonal antibody against UCHL3
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401817) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the N-terminus of human UCHL3 was used as an immunogen.
Clone NameEP5331 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 26 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3), transcript variant 1
Alternative NameUCH-L3
Database LinkNP_001257881
Entrez Gene 7347 Human
Entrez Gene 50933 Mouse
Entrez Gene 498560 Rat
FunctionUCHL3 is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 has a 10-fold preference for Arg and Lys at position P3". It deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. UCHL3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. UCHL3 may be involved in working memory.
Related PathwayProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-UCHL3 antibody [EP5331]; All lanes : Anti-UCHL3 antibody [EP5331] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : SH-SY5Y cell lysate.Lane 4 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.Observed band size : 26 kDa.
Assay Image
Other-Anti-UCHL3 antibody [EP5331](TA310917); Equilibrium disassociation constant (KD)..

 

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