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Anti-UBE3A Antibody EPR7330
Also for UBE3A (NM_000462)
|A synthetic peptide corresponding to residues in human UBE3A was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens ubiquitin protein ligase E3A (UBE3A), transcript variant 2|
|ANCR; AS; E6-AP; EPVE6AP; HPVE6A|
Entrez Gene 7337 Human
Entrez Gene 22215 Mouse
Entrez Gene 361585 Rat
|UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted protein is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this protein causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53 (1). |
|Druggable Genome Ubiquitin mediated proteolysis|
* Availability is in business days
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Western blot - Anti-UBE3A antibody [EPR7330]; All lanes : Anti-UBE3A antibody [EPR7330] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 100 kDa.
Other-Anti-UBE3A antibody [EPR7330](TA310913); Equilibrium disassociation constant (KD)..