The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2C / UBCH10 is a member of the E2 ubiquitin-conjugating enzyme family. It is required for the destruction of mitotic cyclins and for cell cycle progression (1).
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