TMEFF2 is a survival factor for hippocampal and mesencephalic neurons (1). Soluble forms of TMEFF2’s extracellular domain have been reported to weakly stimulate erbB-4/HER4 tyrosine phosphorylation in gastric cancer cells, and they promote the survival of mesencephalic dopaminergic neurons. Elevated TMEFF2 expression is associated with higher prostate cancer grade and hormone independence (2). TMEFF2 is widely expressed in the brain, including hippocampal cornu ammonis, dentate gyrus, and substantia nigra pars compacta (1).
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