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Anti-SSB Antibody EPR6570
|A synthetic peptide corresponding to residues in human SSB was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC/IF: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt.
|Homo sapiens Sjogren syndrome antigen B (autoantigen La) (SSB), transcript variant 1|
|La; La/SSB; LARP3|
|SSB is a highly abundant, largely nuclear phosphoprotein that binds to newly synthesized transcripts of RNA polymerase III. The RNAs bound by this protein include precursors to 5S rRNA, tRNA, the spliceosomal U6 RNA, the signal recognition particle SRP RNA, and the cytoplasmic Y RNAs. At least part of the binding site for SSB on these RNAs is the sequence UUU(OH), which is at the 3-prime end of most newly synthesized transcripts of RNA polymerase III (1). SSB was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus (2). |
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Western blot - Anti-SSB antibody [EPR6570]; All lanes : Anti-SSB antibody [EPR6570] at 1/10000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : K562 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Ramos cell lysate.Lane 5 : C6 cell lysate.Lane 6 : PC12 cell lysate.Lane 7 : NIH 3T3 cell lysate.Lane 8 : RAW 264.7 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled Goat anti Rabbit at 1/2000 dilution.Predicted band size : 46 kDa.Observed band size : 47 kDa .
Other-Anti-SSB antibody [EPR6570](TA310877); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SSB antibody [EPR6570]; TA310877, at 1/250 dilution, staining SSB in paraffin-embedded Human colon tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SSB antibody [EPR6570]; TA310877, at 1/250 dilution, staining SSB in paraffin-embedded Human thyroid adenocarcinoma tissue by Immunohistochemistry.