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Home Antibody All anti-SSB antibodies

Anti-SSB Antibody EPR6570

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SKU Description Amount Price Availability*  
TA310877
  • Rabbit Monoclonal antibody against SSB
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401091) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
IHC(2)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SSB was used as an immunogen.
Clone NameEPR6570 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC/IF: 1:50 - 1:100
Predicted MW Explanation 46 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens Sjogren syndrome antigen B (autoantigen La) (SSB), transcript variant 1
Alternative NameLa; La/SSB; LARP3
Database LinkNP_003133
Entrez Gene 6741 Human
Entrez Gene 20823 Mouse
Entrez Gene 81783 Rat
FunctionSSB is a highly abundant, largely nuclear phosphoprotein that binds to newly synthesized transcripts of RNA polymerase III. The RNAs bound by this protein include precursors to 5S rRNA, tRNA, the spliceosomal U6 RNA, the signal recognition particle SRP RNA, and the cytoplasmic Y RNAs. At least part of the binding site for SSB on these RNAs is the sequence UUU(OH), which is at the 3-prime end of most newly synthesized transcripts of RNA polymerase III (1). SSB was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus (2).
Related PathwayStem cell - PluripotencyTranscription Factors Systemic lupus erythematosus

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-SSB antibody [EPR6570]; All lanes : Anti-SSB antibody [EPR6570] at 1/10000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : K562 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Ramos cell lysate.Lane 5 : C6 cell lysate.Lane 6 : PC12 cell lysate.Lane 7 : NIH 3T3 cell lysate.Lane 8 : RAW 264.7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti Rabbit at 1/2000 dilution.Predicted band size : 46 kDa.Observed band size : 47 kDa .
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Other-Anti-SSB antibody [EPR6570](TA310877); Equilibrium disassociation constant (KD)..
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SSB antibody [EPR6570]; TA310877, at 1/250 dilution, staining SSB in paraffin-embedded Human colon tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SSB antibody [EPR6570]; TA310877, at 1/250 dilution, staining SSB in paraffin-embedded Human thyroid adenocarcinoma tissue by Immunohistochemistry.
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