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Anti-SMAD7 Antibody EPR622


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against Smad7
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Smad7 was used as an immunogen.
Clone NameEPR622 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 46 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens SMAD family member 7 (SMAD7), transcript variant 2
Alternative NameCRCS3; MADH7; MADH8
Database LinkNP_001177750
Entrez Gene 4092 Human
Entrez Gene 17131 Mouse
Entrez Gene 81516 Rat
FunctionSmad7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both Smad7 and TGFBR1. Expression of Smad7 is induced by TGFBR1. Variations in this protein are a cause of susceptibility to colorectal cancer type 3 (CRCS3) (1).
Related PathwayTranscription FactorsDruggable Genome TGF-beta signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-MADH7 antibody [EPR622]; All lanes : Anti-MADH7 antibody [EPR622] at 1/1000 dilution.Lane 1 : Human Uterus lysate.Lane 2 : Human Ovary Cancer lysate.Lane 3 : Human Fetal Lung lysate.Lane 4 : Human Skeletal Muscle lysate.Lane 5 : Human Kidney lysate.Lane 6 : Human Heart lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 46 kDa.
Other-Anti-MADH7 antibody [EPR622](TA310857); Equilibrium disassociation constant (KD)..


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