Smad7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both Smad7 and TGFBR1. Expression of Smad7 is induced by TGFBR1. Variations in this protein are a cause of susceptibility to colorectal cancer type 3 (CRCS3) (1).
TGF Beta Signaling Pathway
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