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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-SMAD7 antibodies

Anti-SMAD7 Antibody EPR622

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA310857
  • Rabbit Monoclonal antibody against Smad7
100ul $325 3-7 Days Add to Shopping Cart
WB(1)
Gene NameHomo sapiens SMAD family member 7 (SMAD7), transcript variant 2
Synonyms:CRCS3; MADH7; MADH8
ImmunogenA synthetic peptide corresponding to residues in human Smad7 was used as an immunogen.
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone NameEPR622 Isotype
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000; IHC 1:100 - 250; ICC: 1:50 - 100; IP: 1:10 - 100;
BackgroundSmad7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both Smad7 and TGFBR1. Expression of Smad7 is induced by TGFBR1. Variations in this protein are a cause of susceptibility to colorectal cancer type 3 (CRCS3) (1).
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot analysis on (A) uterus, (B) ovary cancer, (C) fetal lung, (D) human skeletal muscle, (E) human kidney, and (F) human heart lysates using anti-Smad7 RabMAb.

 

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