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Home Antibody All anti-SLC4A1 antibodies

Anti-SLC4A1 PHOSPHO Antibody EPR1424

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310855
  • Rabbit Monoclonal antibody against AE1, pY21 (SLC4A1) (Phospho-specific)
100ul $325 3-7 Days
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WB(1)
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Also for SLC4A1 (NM_000342)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 21 of human AE1 was used as an immunogen. This antibody only detects AE1 phosphorylated at tyrosine 21.
Clone NameEPR1424 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:50000 - 1:200000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens solute carrier family 4 (anion exchanger), member 1 (Diego blood group) (SLC4A1)
Alternative NameAE1; BND3; CD233; DI; EMPB3; EPB3; FR; RTA1A; SW; WD; WD1; WR
Database LinkNP_000333
FunctionThe AE1 (anion exchanger, band 3) protein is expressed in erythrocytes and in the A-type intercalated cells of the kidney distal collecting tubule. In both cell types it mediates the electroneutral transport of chloride and bicarbonate ions across the lipid bilayer, and, in erythrocytes (1). AE1 is phosphorylated on Tyr8and Tyr21 by SYK. It has been suggested that, upon phosphorylation by p72syk, Tyr8, and Tyr21 act as docking sites for the SH2 domain of Lyn, which subsequently phosphorylates AE1 at additional secondary sites (2).
Related Pathway

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WB Image
Western blot - Anti-Band 3 (phospho Y21) antibody [EPR1424]; All lanes : Anti-Band 3 (phospho Y21) antibody [EPR1424] at 1/50000 dilution.Lane 1 : Human red blood cell lysate, untreated.Lane 2 : Human red blood cell lysate, Pervanadate treated.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.developed using the ECL technique.Predicted band size : 101 kDa.

 

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