The AE1 (anion exchanger, band 3) protein is expressed in erythrocytes and in the A-type intercalated cells of the kidney distal collecting tubule. In both cell types it mediates the electroneutral transport of chloride and bicarbonate ions across the lipid bilayer, and, in erythrocytes (1). AE1 is phosphorylated on Tyr359 and Tyr404 by Lyn in erythrocytes. Phosphorylation of these residues is necessary for correct localization and recycling of kidney AE1 to the basolateral membrane (2).
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A. Western blot analysis on red blood cell lysate using anti-Phospho-AE1 (pY359) RabMAb, 1:50,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.
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