S100A4 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and they are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 proteins include at least 13 members. S100A4 may function in motility, invasion, and tubulin polymerization. Altered expression of S100A4 have been implicated in tumor metastasis.
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