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Home Antibody All anti-RCC1 antibodies

Anti-RCC1 Antibody EPR5857

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310817
  • Rabbit Monoclonal antibody against RCC1
100ul 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RCC1 was used as an immunogen.
Clone NameEPR5857 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:500 - 1:1000
Predicted MW Explanation 45 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens regulator of chromosome condensation 1 (RCC1), transcript variant 1
Alternative NameCHC1; RCC1-I; SNHG3-RCC1
Database LinkNP_001041659
Entrez Gene 1104 Human
Entrez Gene 100088 Mouse
Entrez Gene 682908 Rat
FunctionRCC1, or Regulator of chromosome condensation 1, is the guanine nucleotide exchange factor for Ran GTPase. Localized generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation. Both the N-terminal tail of RCC1 and its association with Ran are important for its interaction with chromatin in cells, demonstrated by RCC1’s ability to bind histones H2A and/or H2B in a Ran-regulated manner (1, 2). RCC1 also binds both to the nucleosomes and double-stranded DNA. The RCC1-Ran complex, together with other proteins, acts as a component of a signal transmission pathway that detects unreplicated DNA (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - RCC1 antibody [EPR5857]; All lanes : Anti-RCC1 antibody [EPR5857] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 45 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RCC1 antibody [EPR5857]; TA310817, at a 1/100 dilution, staining RCC1 in paraffin-embedded Human bladder carcinoma tissue

 

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