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Anti-RCC1 Antibody EPR5857
Also for RCC1 (NM_001048194)
|A synthetic peptide corresponding to residues in human RCC1 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:500 - 1:1000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt.
|Homo sapiens regulator of chromosome condensation 1 (RCC1), transcript variant 1|
|CHC1; RCC1-I; SNHG3-RCC1|
|RCC1, or Regulator of chromosome condensation 1, is the guanine nucleotide exchange factor for Ran GTPase. Localized generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation. Both the N-terminal tail of RCC1 and its association with Ran are important for its interaction with chromatin in cells, demonstrated by RCC1’s ability to bind histones H2A and/or H2B in a Ran-regulated manner (1, 2). RCC1 also binds both to the nucleosomes and double-stranded DNA. The RCC1-Ran complex, together with other proteins, acts as a component of a signal transmission pathway that detects unreplicated DNA (3).|
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Western blot - RCC1 antibody [EPR5857]; All lanes : Anti-RCC1 antibody [EPR5857] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 45 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RCC1 antibody [EPR5857]; TA310817, at a 1/100 dilution, staining RCC1 in paraffin-embedded Human bladder carcinoma tissue