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Anti-RANBP3 Antibody EPR5088(2)

WB(1)

IHC(1)

Gene Name Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a Synonyms: DKFZp586I1520 Immunogen A synthetic peptide corresponding to residues in human RanBP3 was used as an immunogen. Buffer Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. Clone Name EPR5088(2) Isotype Species Reactivity Human, Mouse Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 1:1,000 - 10,000; Background RanBP3 is a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. It plays a role in nuclear export as part of a heteromeric complex (1). RanBP3 binds to the Crm1 transport receptor and inhibits the binding of unloaded Crm1 to the NPC. In addition, it increases the affinity of Crm1 for both Ran-GTP and nuclear export sequences. In this manner, RanBP3 coordinates efficient cargo loading and RanGTP binding (2). Moreover, RanBP3 has been shown to bind to RCC1 in a Ran-dependent manner and to increase the nucleotide exchange activity of RCC1, resulting in high concentrations of RanGTP in the vicinity of RCC1. Consequently, RanBP3 acts as a scaffold protein by which components of the export complex are concentrated around the RCC1 site, thus promoting complex assembly (3). Related Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • RANBP3 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • RANBP3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Ranbp3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • RANBP3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Ranbp3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a as transfection-ready DNA Related cDNA Clones • Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)