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Home Antibody All anti-RANBP3 antibodies

Anti-RANBP3 Antibody EPR5088(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310810
  • Rabbit Monoclonal antibody against RanBP3
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for RANBP3 (NM_003624)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RanBP3 was used as an immunogen.
Clone NameEPR5088(2) IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:100 - 1:500
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a
Alternative NameDKFZp586I1520
Database LinkNP_003615
FunctionRanBP3 is a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. It plays a role in nuclear export as part of a heteromeric complex (1). RanBP3 binds to the Crm1 transport receptor and inhibits the binding of unloaded Crm1 to the NPC. In addition, it increases the affinity of Crm1 for both Ran-GTP and nuclear export sequences. In this manner, RanBP3 coordinates efficient cargo loading and RanGTP binding (2). Moreover, RanBP3 has been shown to bind to RCC1 in a Ran-dependent manner and to increase the nucleotide exchange activity of RCC1, resulting in high concentrations of RanGTP in the vicinity of RCC1. Consequently, RanBP3 acts as a scaffold protein by which components of the export complex are concentrated around the RCC1 site, thus promoting complex assembly (3).
Related Pathway

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WB Image
Western blot - Anti-RanBP3 antibody [EPR5088(2)]; Anti-RanBP3 antibody [EPR5088(2)] at 1/1000 dilution + 293T lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 60 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RanBP3 antibody [EPR5088(2)]; Immunohistochemical analysis of paraffin-embedded Human testis tissue labelling RanBP3 with TA310810 at 1/100 dilution.

 

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