Home Antibody All anti-RAD50 antibodies
Anti-RAD50 Antibody EPR3466(2)
Also for RAD50 (NM_005732)
|A synthetic peptide corresponding to residues in human Rad50 was used as an immunogen.|
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||ICC/IF: Use at an assay dependent concentration; WB: 1:1000 - 1:10000
|pH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens RAD50 homolog (S. cerevisiae) (RAD50)|
|hRad50; NBSLD; RAD502|
Entrez Gene 10111 Human
Entrez Gene 19360 Mouse
|Rad50 is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. It forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. Rad50, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest Rad50 is essential for cell growth and viability. Mutations in Rad50 are the cause of Nijmegen breakage syndrome-like disorder (1).|
|Druggable Genome Homologous recombinationNon-homologous end-joining|
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Western blot - Anti-Rad50 antibody [EPR3466(2)]; All lanes : Anti-Rad50 antibody [EPR3466(2)] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : MOLT4 cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 154 kDa.Observed band size : 150 kDa .