DNA-PK/PRKDC, the catalytic subunit of the DNA-dependent protein kinase, is a member of the PI3/PI4-kinase family. It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination (1). Autophosphorylation of DNA-PK correlates with loss of protein kinase activity and dissociation of the DNA-PKcs-Ku complex. DNA-PK phosphorylates Hsp90, p53 and c-Jun (2,3).
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Western blot analysis on LnCaP cell lysates using anti-Phospho-DNA-PK/PRKDC (pS2612) RabMAb. Cells were either (A,C) untreated or (B,D) treated with alkaline phosphatase (AP).<br>Lane C and D were probed using pan DNA-PK/PRKDC RabMAb
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