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Home Antibody All anti-PRKDC antibodies

Anti-PRKDC PHOSPHO Antibody EPR2251


Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against DNA-PK/PRKDC (pS2612) (Phospho-specific)
100ul 325 3-7 Days
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Also for PRKDC (NM_006904)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 2612 of human DNA-PK/PRKDC was used as an immunogen. This antibody only detects DNA-PK/PRKDC phosphorylated at serine 2612.
Clone NameEPR2251 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1
Alternative NameDNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; IMD26; p350; XRCC7
Database LinkNP_008835
Entrez Gene 5591 Human
FunctionDNA-PK/PRKDC, the catalytic subunit of the DNA-dependent protein kinase, is a member of the PI3/PI4-kinase family. It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination (1). Autophosphorylation of DNA-PK correlates with loss of protein kinase activity and dissociation of the DNA-PKcs-Ku complex. DNA-PK phosphorylates Hsp90, p53 and c-Jun (2,3).
Related PathwayProtein KinaseDruggable Genome Non-homologous end-joiningCell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-DNA PKcs (phospho S2612) antibody [EPR2251]; All lanes : Anti-DNA PKcs (phospho S2612) antibody [EPR2251] at 1/1000 dilution.Lane 1 : Lysate of LNCaP cells, untreated .Lane 2 : Lysate of LNCaP cells treated with alkaline phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated goat anti-rabbit antibody at 1/2000 dilution.Predicted band size : 469 kDa.


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