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Home Antibody All anti-PLAU antibodies

Anti-PLAU Antibody EPR6273

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SKU Description Amount Price Availability*  
TA310763 Rabbit Monoclonal antibody against PLAU 100ul $325 In Stock
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WB(1)
FC(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PLAU was used as an immunogen.
Clone NameEPR6273 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, FC Suggested DilutionsFC: 1:100 - 1:500; IP: 1:10 - 1:100; WB: 1:1000 - 1:10000
Predicted MW Explanation 49 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens plasminogen activator, urokinase (PLAU), transcript variant 2
Alternative NameATF; BDPLT5; QPD; u-PA; UPA; URK
Database LinkNP_001138503
Entrez Gene 5328 Human
Entrez Gene 18792 Mouse
Entrez Gene 25619 Rat
FunctionPLAU is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific mutation in PLAU may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. It converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor (1).
Related PathwayES Cell Differentiation/IPSProteaseDruggable Genome Complement and coagulation cascades

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-Urokinase antibody [EPR6273]; All lanes : Anti-Urokinase antibody [EPR6273] at 1/1000 dilution.Lane 1 : PC3 cell lysate.Lane 2 : LNCaP cell lysate.Lane 3 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.developed using the ECL technique.Predicted band size : 49 kDa.
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Other-Anti-Urokinase antibody [EPR6273](TA310763); Equilibrium disassociation constant (KD)..
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Flow Cytometry - Anti-Urokinase antibody [EPR6273]; Flow cytometry analysis of permeabilized MCF7 cells staining Urokinase using TA310763 at a 1/100 dilution (red) or a rabbit IgG negative control (green).
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