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Anti-PF4 Antibody EPR7763
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|A synthetic peptide corresponding to residues in human PF4 was used as an immunogen.|
||WB: 1:1,000 - 10,000; IP: 1:10 - 100;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens platelet factor 4 (PF4)|
|CXCL4; PF-4; SCYB4|
|PF4, or Platelet factor-4, is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (1).|
Cytokine-cytokine receptor interaction
Signaling by GPCR
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Western blot analysis on (A) human spleen and (B) human platelet lysates using anti-PF4 RabMAb.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-PF4 RabMAb.