Anti-PCK1 Antibody, EPR6938

Also for PCK1 (NM_002591)

Gene Name	Homo sapiens phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1)
Synonyms:	PEPCK-C; PEPCK1; PEPCKC
Immunogen	A synthetic peptide corresponding to residues in human PCK1 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR6938	Isotype
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000; FC: 1:100 - 500;
Background	PCK1 is a main control point for the regulation of gluconeogenesis. It is a cytosolic enzyme, along with GTP, that catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of PCK1 can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in PCK1 are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of this protein also has been characterized (1).
Related Pathway	Adipogenesis

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WB Image

Western blot analysis on (A) fetal kidney and (B) human adipose tissue lysates using anti-PCK1 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-PCK1 RabMAb.

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FITC
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Anti-PCK1 Antibody EPR6938

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