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Anti-NUP96 Antibody EPR6678
Also for NUP96 (NM_005387)
|A synthetic peptide corresponding to residues in human NUP96 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC/IF: 1:50 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens nucleoporin 98kDa (NUP98), transcript variant 3|
|ADIR2; NUP196; NUP96|
|Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. NUP96 has been shown to fuse to several proteins through mutations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). It is an important tumor-suppressor protein. Mutations in NUP96 have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer (1). |
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Western blot - Anti-NUP98 antibody [EPR6678]; All lanes : Anti-NUP98 antibody [EPR6678] at 1/1000 dilution.Lane 1 : HeLa cell lysates.Lane 2 : SH-SY5Y cell lysates.Lane 3 : Caco-2 cell lysates.Lysates/proteins at 10 µg per lane.Predicted band size : 188 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUP98 antibody [EPR6678]; ab124980, at 1/50 to 1/100, staining NUP98 in Human colon tissue by immunohistochemistry [Paraffin Embedded Tissues (IHC-P)].