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Home Antibody All anti-NR1H4 antibodies

Anti-NR1H4 Antibody EPR5721

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310730
  • Rabbit Monoclonal antibody against NR1H4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401577) , 20ug Explanation
100ul 325 In Stock
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WB(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human NR1H4 was used as an immunogen.
Clone NameEPR5721 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 56 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens nuclear receptor subfamily 1, group H, member 4 (NR1H4), transcript variant 6
Alternative NameBAR; FXR; HRR-1; HRR1; RIP14
Database LinkNP_001193906
Entrez Gene 9971 Human
Entrez Gene 20186 Mouse
Entrez Gene 60351 Rat
FunctionNR1H4 is a ligand-activated transcription factor, and is receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. It represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. NR1H4 activates the intestinal bile acid-binding protein (IBABP), and the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (1).
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Bile Acid Receptor NR1H4 antibody [EPR5721]; All lanes : Anti-Bile Acid Receptor NR1H4 antibody [EPR5721] at 1/1000 dilution.Lane 1 : Human fetal liver lysate.Lane 2 : HepG2 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 56 kDa.
Assay Image
Other-Anti-Bile Acid Receptor NR1H4 antibody [EPR5721](TA310730); Equilibrium disassociation constant (KD)..

 

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