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Anti-NR1H4 Antibody EPR5721
Also for NR1H4 (NM_001206977)
|A synthetic peptide corresponding to residues in human NR1H4 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens nuclear receptor subfamily 1, group H, member 4 (NR1H4), transcript variant 6|
|BAR; FXR; HRR-1; HRR1; RIP14|
|NR1H4 is a ligand-activated transcription factor, and is receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. It represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. NR1H4 activates the intestinal bile acid-binding protein (IBABP), and the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (1). |
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Western blot - Anti-Bile Acid Receptor NR1H4 antibody [EPR5721]; All lanes : Anti-Bile Acid Receptor NR1H4 antibody [EPR5721] at 1/1000 dilution.Lane 1 : Human fetal liver lysate.Lane 2 : HepG2 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 56 kDa.
Other-Anti-Bile Acid Receptor NR1H4 antibody [EPR5721](ab126602); Equilibrium disassociation constant (KD)..