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Anti-NPC1 Antibody EPR5209
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for NPC1 (NM_000271)
|A synthetic peptide corresponding to residues at the C-terminus of human NPC1 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000; IHC 1:50 - 100;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens Niemann-Pick disease, type C1 (NPC1)|
|NPC1 is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this protein cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by overaccumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments (1).|
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Western blot analysis on (A) 3T3-L1, (B) L6, (C) HepG2, (D) THP-1, (E) 293T, (F) PC-3, (G) rat liver, and (H) rat brain lysates using anti-NPC1 RabMAb.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-NPC1 RabMAb.