MC5R is a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. It is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation (1). MC5R is expressed in the brain but not in the melanoma cells (2).
Signaling by GPCR
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