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Home Antibody All anti-LTA4H antibodies

Anti-LTA4H Antibody EPR5712

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310667
  • Rabbit Monoclonal antibody against LTA4H
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424467) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
Assay(1)
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Also for LTA4H (NM_000895)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human LTA4H was used as an immunogen.
Clone NameEPR5712 IsotypeTissue culture supernatant
Species ReactivityRat, Human (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; FC: 1:100 - 1:500
BufferDoes not react with Mouse. Is unsuitable for ICC.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens leukotriene A4 hydrolase (LTA4H), transcript variant 1
Alternative Nameleukotriene A4 hydrolase
Database LinkNP_000886
Entrez Gene 4048 Human
Entrez Gene 299732 Rat
FunctionThe leukotrienes are a group of proinflammatory lipid mediators that have been implicated in the pathogenesis and progression of atherosclerosis. LTA4H, or leukotriene A4 hydrolase, is a bifunctional enzyme with aminopeptidase and epoxide hydrolase activities that utilize a single zinc active site (1). The aminopeptidase activity of LTA4H, but not epoxide hydrolase activity, highly depends on certain monovalent anions, especially chloride and thiocyanate ions (2). As a member of the peptidase M1 family, LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4), which acts as a chemoattractant and an activator of inflammatory responses mediated by binding to G-protein-coupled receptors BLT1 and BLT2 (1, 3).
Related PathwayProteaseDruggable Genome Arachidonic acid metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Leukotriene A4 hydrolase antibody [EPR5712]; All lanes : Anti-Leukotriene A4 hydrolase antibody [EPR5712] at 1/10000 dilution.Lane 1 : HeLa cell lysate .Lane 2 : 293T cell lysate.Lane 3 : T47D cell lysate.Lane 4 : A549 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 69 kDa.
Assay Image
Other-Anti-Leukotriene A4 hydrolase antibody [EPR5712](TA310667); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Leukotriene A4 hydrolase antibody [EPR5712]; Immunohistochemical analysis of Leukotriene A4 hydrolase in paraffin-embedded Human breast carcinoma tissue using TA310667 at 1/250 dilution.

 

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