Anti-LTA4H Antibody, EPR5712

Also for LTA4H (NM_000895)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human LTA4H was used as an immunogen.
Clone Name	EPR5712	Isotype
Species Reactivity	Human, Rat	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:100 - 250; ICC: 1:100 - 250; IP: 1:10 - 100;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens leukotriene A4 hydrolase (LTA4H), transcript variant 1
Alternative Name	leukotriene A4 hydrolase
Database Link	NP_000886
Function	The leukotrienes are a group of proinflammatory lipid mediators that have been implicated in the pathogenesis and progression of atherosclerosis. LTA4H, or leukotriene A4 hydrolase, is a bifunctional enzyme with aminopeptidase and epoxide hydrolase activities that utilize a single zinc active site (1). The aminopeptidase activity of LTA4H, but not epoxide hydrolase activity, highly depends on certain monovalent anions, especially chloride and thiocyanate ions (2). As a member of the peptidase M1 family, LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4), which acts as a chemoattractant and an activator of inflammatory responses mediated by binding to G-protein-coupled receptors BLT1 and BLT2 (1, 3).
Related Pathway

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WB Image

Western blot analysis on (A) HeLa, (B) 293T, (C) T47-D, and (D) A549 cell lysates using anti-LTA4H RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-LTA4H RabMAb.

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Anti-LTA4H Antibody EPR5712

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data