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Anti-LTA4H Antibody EPR5712
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Also for LTA4H (NM_000895)
|A synthetic peptide corresponding to residues in human LTA4H was used as an immunogen.|
||WB: 1:1,000 - 10,000; IHC 1:100 - 250; ICC: 1:100 - 250; IP: 1:10 - 100;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens leukotriene A4 hydrolase (LTA4H), transcript variant 1|
|leukotriene A4 hydrolase|
|The leukotrienes are a group of proinflammatory lipid mediators that have been implicated in the pathogenesis and progression of atherosclerosis. LTA4H, or leukotriene A4 hydrolase, is a bifunctional enzyme with aminopeptidase and epoxide hydrolase activities that utilize a single zinc active site (1). The aminopeptidase activity of LTA4H, but not epoxide hydrolase activity, highly depends on certain monovalent anions, especially chloride and thiocyanate ions (2). As a member of the peptidase M1 family, LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4), which acts as a chemoattractant and an activator of inflammatory responses mediated by binding to G-protein-coupled receptors BLT1 and BLT2 (1, 3). |
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Western blot analysis on (A) HeLa, (B) 293T, (C) T47-D, and (D) A549 cell lysates using anti-LTA4H RabMAb.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-LTA4H RabMAb.