Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
LIN28A, a promoter of pluripotency, is a developmentally regulated RNA binding protein, which selectively blocks the processing of pri-let-7 miRNAs in embryonic cells (1,2). One of the let-7 family members, let-7g targets and represses LIN28 through four 3'-UTR binding sites. It has been reported that LIN28/let-7 pair has the potential to act as a 'toggle switch' that balances the decision to maintain pluripotency vs. differentiation (3). LIN28 was identified as a negative regulator of miRNA biogenesis and suggested that it may play a central role in blocking miRNA-mediated differentiation in stem cells and in certain cancers (1).
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