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Anti-KLKB1 Antibody EPR5707
Also for KLKB1 (NM_000892)
|A synthetic peptide corresponding to residues in the C-terminus of human KLKB1 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, Assay, IHC
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens kallikrein B, plasma (Fletcher factor) 1 (KLKB1)|
Entrez Gene 3818 Human
|KLKB1 (Plasma prekallikrein) is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. KLKB1 is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. This protein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of KLKB1. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. KLKB1 deficiency causes a prolonged activated partial thromboplastin time in patients (1). |
|ProteaseDruggable Genome Complement and coagulation cascades|
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Western blot - Anti-Plasma Kallikrein 1B antibody [EPR5707]; All lanes : Anti-Plasma Kallikrein 1B antibody [EPR5707] at 1/1000 dilution.Lane 1 : Human breast cancer lysate.Lane 2 : Human plasma lysate.Lane 3 : Human ovary lysate.Lane 4 : Fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti Rabbit IgG at 1/2000 dilution.Predicted band size : 71 kDa.Observed band size : 80 kDa .
Other-Anti-Plasma Kallikrein 1B antibody [EPR5707](TA310647); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Kallikrein 1B antibody [EPR5707]; TA310647, at 1/50 dilution, staining Plasma Kallikrein 1B in paraffin-embedded Human kidney tissue by Immunohistochemistry.