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Home Antibody All anti-KLKB1 antibodies

Anti-KLKB1 Antibody EPR5707


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310647 Rabbit Monoclonal antibody against KLKB1 100ul $325 In Stock
LC400318 KLKB1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-terminus of human KLKB1 was used as an immunogen.
Clone NameEPR5707 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100
Predicted MW Explanation 71 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens kallikrein B1 (KLKB1), transcript variant 1
Alternative NameKLK3; PPK
Database LinkNP_000883
Entrez Gene 3818 Human
FunctionKLKB1 (Plasma prekallikrein) is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. KLKB1 is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. This protein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of KLKB1. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. KLKB1 deficiency causes a prolonged activated partial thromboplastin time in patients (1).
Related PathwayProteaseDruggable Genome Complement and coagulation cascades

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Plasma Kallikrein 1B antibody [EPR5707]; All lanes : Anti-Plasma Kallikrein 1B antibody [EPR5707] at 1/1000 dilution.Lane 1 : Human breast cancer lysate.Lane 2 : Human plasma lysate.Lane 3 : Human ovary lysate.Lane 4 : Fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti Rabbit IgG at 1/2000 dilution.Predicted band size : 71 kDa.Observed band size : 80 kDa .

Assay Image
Other-Anti-Plasma Kallikrein 1B antibody [EPR5707](TA310647); Equilibrium disassociation constant (KD)..

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Kallikrein 1B antibody [EPR5707]; TA310647, at 1/50 dilution, staining Plasma Kallikrein 1B in paraffin-embedded Human kidney tissue by Immunohistochemistry.


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