OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-KLKB1 antibodies

Anti-KLKB1 Antibody EPR5707

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310647
  • Rabbit Monoclonal antibody against KLKB1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400318) , 20ug Explanation
100ul 325 In Stock
Add to Shopping Cart
WB(1)
IHC(1)
Assay(1)
spacer
Also for KLKB1 (NM_000892)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-terminus of human KLKB1 was used as an immunogen.
Clone NameEPR5707 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100
Predicted MW Explanation 71 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens kallikrein B, plasma (Fletcher factor) 1 (KLKB1)
Alternative NameKLK3; PPK
Database LinkNP_000883
Entrez Gene 3818 Human
FunctionKLKB1 (Plasma prekallikrein) is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. KLKB1 is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. This protein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of KLKB1. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. KLKB1 deficiency causes a prolonged activated partial thromboplastin time in patients (1).
Related PathwayProteaseDruggable Genome Complement and coagulation cascades

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Plasma Kallikrein 1B antibody [EPR5707]; All lanes : Anti-Plasma Kallikrein 1B antibody [EPR5707] at 1/1000 dilution.Lane 1 : Human breast cancer lysate.Lane 2 : Human plasma lysate.Lane 3 : Human ovary lysate.Lane 4 : Fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti Rabbit IgG at 1/2000 dilution.Predicted band size : 71 kDa.Observed band size : 80 kDa .
Assay Image
Other-Anti-Plasma Kallikrein 1B antibody [EPR5707](TA310647); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Kallikrein 1B antibody [EPR5707]; TA310647, at 1/50 dilution, staining Plasma Kallikrein 1B in paraffin-embedded Human kidney tissue by Immunohistochemistry.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title